Tesamorelin: The GH Releasing Hormone

If you’re looking for another peptide therapy that can help your body release more growth hormones, then the Tesamorelin might just be the peptide you’re looking for.

Today, we’re going to get to know more about this GH releasing hormone. Read along; you may just need one for yourselves.

What Is Tesamorelin?

Tesamorelin is a growth-hormone-releasing analog that can increase IGF-1 levels in both men and women by an average of 181 micrograms/liter. This growth hormone can bind and stimulate the GHRH receptors that have a similar potency with GHRH.

This growth hormone also hosts many benefits which include:

  • Nootropic effects
  • Reducing triglycerides

Tesamorelin has shown to decrease carotid intima-media thickness (cIMT), visceral adipose tissue (VAT) and c-reactive protein (CRP.) Although, this growth hormone has not been linked to significantly affect other pituitary hormones and other respective mechanisms of the body. 

Besides, Tesamorelin can also improve cognitive function for people with old age, and patients who suffer increase risk in Alzheimer’s disease due to mild cognitive impairment. 

Content & Potency

The Tesamorelin/Ipamorelin is available in 6mg/1.5 mg Lyophilized Kit with 4 vials per kit for subcutaneous injection.

Suggested Dosage

For its dosage, ensure to reconstitute each vial with 3 m: and inject 0.5 mL subcutaneously before bed 6 out of 7 nights 90 minutes after your last food intake. One vial should be reconstituted at a time. 

Clinical Research

no-abdominal-fat

Strategies have been done to augment pulsatile GH. This is known to benefit patients with excessive visceral adiposity where GH secretion is reduced. 

The study’s objective was to determine all the effects of a novel GHTH analog, tesamorelin, to endogenous GH pulsatility and insulin sensitivity in healthy males.

Thirteen males from ages 45 to 47 with a body mass index of 27.3 to 1.2kg were given tesamorelin 2mg once daily for two weeks. The assessments were made after two weeks of treatment and as well as two weeks of withdrawal.

At the end of the study, it was found that once-daily short-term treatment with GHRH1-44 analog, tesamorelin, augments basal, and pulsatile GH secretion.

Besides, although tesamorelin significantly increases IGF-1, peripheral insulin-stimulated glucose was observed. 

Clinical trials of tesamorelin have also been seen to reduce abdominal fat’s fewer side effects than the human growth hormone itself. Although, abdominal fat can return after the tesamorelin is discontinued depending on the preference of the individual taking it. 

Tesamorelin has also been shown to reduce lipodystrophy in HIV-infected individuals as well as similarly reducing the abdominal fat found in NON-HIV infected individuals.

What Are The Benefits Of Tesamorelin?

Here is a list of benefits brought about by taking Tesamorelin:

  • Increased production of HGH (human growth hormone)
  • Increases IGF-1 or the Insulin Growth Factor-1 without needing to alter glucose parameters
  • Reduced triglycerides
  • Reduced Visceral Adipose Tissue (VAT)
  • Reduced Carotid Intima-Media Size (cIMT)
  • Improved cognition in adults who are over the age of 60

What Are The Side Effects Of Tesamorelin?

Here are some side effects you may experience when taking Tesamorelin. Also, make sure you inform your doctors or health care professionals right away by any chance you are experiencing such:

  • Allergic reaction:

-Skin rashes

-Itching

-Hives

-Swelling of face, tongue, or lips

  • Chest pain or chest tightness
  • Increased hunger or thirst
  • Increased urination
  • Feeling weak and tired
  • Palpitations

Here are some other side effects in taking this medicine (which do not really require medical attention.) Although, make sure to inform your healthcare providers if you think these are being bothersome:

  • Depressed mood
  • Muscle pain
  • Nausea
  • Vomiting
  • Pain
  • Redness or irritation of site that was injected
  • Tingling or numbness of hands and feet
  • Swelling of ankles, feet, or hands

What Should You Tell Your Healthcare Provider Before Taking This Medicine?

Before taking this medicine, your healthcare provider must know if you have any of the following conditions:

  • cancer
  • Head injury
  • Recently concluded or ongoing head radiation therapy
  • Problems in the pituitary gland (including tumor)
  • Diabetes
  • Recent surgery 
  • Unusual allergic reaction to tesamorelin, mannitol, medicines, food, hair dye, or preservatives
  • Currently breast-feeding

What Is The Right Way To Use Tesamorelin?

Taking-Tesamorelin-Injection

The appropriate way to use Tesamorelin is to inject it under your skin. Although you can be taught how to prepare and give this medicine to yourself. Make sure you do exactly as directed as your health care provider and take this at regular intervals. Never take this medicine more than often as what was directed to you.

It is essential that you put your used needles and syringes in a  sharp container. Never put them in the trash can. If you do not have sharp containers, call your health care providers, and secure one for yourself. 

Never use this medicine by any chance, it has solid particles in it or looks quite cloudy or colored. This should be clear and colorless.

A patient package insert for the product will be given to you. Each will have a prescription and as well as a refill. Ensure you read this information carefully before administering it.

Make sure to talk to your pediatrician by any chance you will be using it for children since special care may be needed. 

What Will Happen If I Miss A Dose?

By any chance, you accidentally miss a dose, make sure to take it as soon as possible. If it is almost time for the next dose, don’t take a double dose. Only take one. 

What May Interact With This Medicine?

Here are the following which may interact with this medicine:

  • Cortisone
  • Prednisone
  • Ritonavir
  • Simvastatin

Although this list might not state all possible interactions, make sure you give your health care providers a list of all medications and dietary supplements that you are currently using before taking Tesamorelin.

Make sure to be transparent with them and inform them if you smoke, drink alcohol, or use illegal drugs. Some may interact with Tesamorelin.

What Should I Look Out For When Taking This Medicine?

Make sure you visit your doctors and healthcare providers for regular check-ups to see the progress you’ve made so far. Your doctor might order you to go through blood tests and other laboratory tests to see how you’re doing.

If you are a diabetic patient, make sure you check your blood sugar as directed.

This medicine may also harm an unborn child; thus, women taking this medicine should avoid getting pregnant. If pregnancy would occur, make sure you stop this medicine at once. 

Bottomline

Overall, Tesamorelin is known to give numerous benefits to the body. Although, you need to ensure that you consult your medical practitioners first before taking any of it.

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